hepatomegaly in Japanese
Cases of lactic acidosis, sometimes fatal, usually associated with severe hepatomegaly and hepatic steatosis, have been reported with the use of nucleoside analogues (see section 4.4).
Caution should be exercised when administering nucleoside analogues to any patient (particularly obese women) with hepatomegaly, hepatitis or other known risk factors for liver disease and hepatic steatosis (including certain medicinal products and alcohol).
Caution should be exercised when prescribing nucleoside analogues to any patient (particularly obese women) with hepatomegaly, hepatitis or other known risk factors for liver disease.
hepatic failure (see section 4.4), gamma- glutamyltransferase increased, jaundice, cholestasis, hepatomegaly, hepatitis
Hepatomegaly, jaundice, hyperbilirubinemia* Hepatotoxicity (including fatalities)*
Jaundice, cholestatic jaundice Hepatic failure, hepatitis, hepatomegaly, cholecystitis, cholelithiasis
Lactic acidosis and severe hepatomegaly with steatosis:
Liver disorders such as severe hepatomegaly with steatosis
Not known: hepatotoxicity, hepatomegaly, jaundice.
Occurrence of lactic acidosis (in the absence of hypoxaemia) sometimes fatal, and usually associated with severe hepatomegaly with steatosis have been reported with the use of nucleoside/ nucleotide analogues.
abnormal enlargement of the liver: abnormality, megalohepatia, abnormalcy